Transfersome technology was developed to deliver drugs and other molecules into and through the skin non-invasively. Indeed, the FLEXISEQ® development programme was part of a programme to develop a locally-targeted ketoprofen product. Transfersomes use the same core technology as Sequessome Technology®, namely deformable, phospholipid-surfactant vesicles, which are drawn into and through the skin driven by the water gradient.
Transfersomes can be used for local delivery of agents to avoid systemic exposure and side effects.
Transfersomes are able to pass through the skin because they are ultra-deformable and can pass through the tiny intracellular spaces in the skin. However, they are also stable and remain intact allowing them to be effective carriers.