Chaperones

Chaperones are PEGylated liposomes that can be used alone or in conjunction with proteins, and applied either intravenously or subcutaneously to escort (“chaperone”) exogenous and endogenous proteins and peptides in the body to improve their therapeutic profile.

These liposomes use polyethyleneglycol (PEG) attached to the head group of a fatty acid chain that is embedded in the wall of the vesicle. The PEG provides some very useful attributes to the Chaperone vesicle, in particular it cloaks the vesicle in a sphere of water, meaning the Chaperoned protein or peptide has a longer half-life in the body, extending dosing intervals, reducing dosing amounts, and saving costs. In addition, the presence of PEG can allow for products to be administered subcutaneously, when they were previously only able to be administered intravenously.